Rory McIlroy missed his first cut since the 2019 Open after filming the second round of 76 at Genesis Invitational.
McIlroy has performed at 30 events since his Friday at the Open in his native Northern Ireland.
The Northern Irishman carded one birdie, four excavators and a double excavator to fall to seven above the level.
Burns himself hit an uninformed 66 with 12 goals less, knocking him out of a group that includes Dustin Johnson.
Burns led after the opening 64, and his overall score below 12 below equaled the track record of 36 holes.
Padraig Harrington, who will be competing in his first competition since returning after a positive test at Covid-19, will also miss the match for the weekend after the European Ryder Cup captain hit 76 and dropped to nine more than the level.
Hoping to bounce after the inaugural 73, McIlroy dropped a bullet at 12, his third hole, and as he retaliated with a birdie at 13, the four-time main winner fired further shots at 14, 17 and 18.
After a series of seven consecutive games on the back of nine, the two-color six on the eighth surpassed a disappointing week for the 31-year-old, who had the longest series of active cuts on the PGA Tour at 25 before this week.
McIlroy will return to action on Thursday at the World Golf Championships in Florida, which was relocated from Mexico due to the pandemic.
World number one Johnson shares second place with compatriots Tyler McCumber and Jason Kokrak and Chilean Joaquin Niemann.
Jordan Spieth is a further blow in the group, with Englishman Matthew Fitzpatrick remaining overnight at position five below 71 and Brooks Koepka among those at four less.
McIlroy wasn’t the only big name to miss the cut, as Bryson knocked out DeChambeau on two and Justin Thomas with a kick behind the Northern Irishman on eight.